Falciparum malaria resistant to chloroquine and Fansidar: implications for prophylaxis.
نویسندگان
چکیده
منابع مشابه
Chloroquine-resistant falciparum malaria from Africa.
FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of limited value. All malariologists have dreaded the day when chloroquine-resistant malaria from A...
متن کاملA molecular marker for chloroquine-resistant falciparum malaria.
BACKGROUND Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa. Chloroquine resistance has been associated in vitro with point mutations in two genes, pfcrt and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1, respectively. METHODS To assess the value of these mutations as markers for...
متن کاملHigh-Dose Chloroquine for Treatment of Chloroquine-Resistant Plasmodium falciparum Malaria.
BACKGROUND Due to development of multidrug-resistant Plasmodium falciparum new antimalarial therapies are needed. In Guinea-Bissau, routinely used triple standard-dose chloroquine remained effective for decades despite the existence of "chloroquine-resistant" P. falciparum. This study aimed to determine the in vivo efficacy of higher chloroquine concentrations against P. falciparum with resista...
متن کاملChloroquine-resistant Plasmodium falciparum cerebral malaria in a chloroquine-susceptible area.
Chloroquine-resistant Plasmodium falciparum is endemic in many areas. Saudi Arabia was considered to have chloroquine-susceptible P. falciparum. During the 1997-1998 season, an outbreak of malaria occurred in the southwestern region. Over a 4-month period, 32 cases (6.2%) of 520 malaria admissions met the World Health Organization criteria for cerebral malaria. The mean patient age was 28 years...
متن کاملChloroquine/Sulphadoxine-Pyrimethamine for Gambian Children with Malaria: Transmission to Mosquitoes of Multidrug-Resistant Plasmodium falciparum
OBJECTIVES In the Gambia, chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) is the first-line antimalarial treatment. Plasmodium falciparum parasites carrying mutations associated with resistance to each of these drugs were present in 2001 but did not cause a significant loss of therapeutic efficacy among children receiving the combination CQ/SP. We measured their effect on parasite transmi...
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ژورنال
عنوان ژورنال: BMJ
سال: 1984
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.288.6417.644-d